Omaprin® 20

Omeprazole

OMAPRIN (Omeprazole), a substituted benzimidazole, is an inhibitor of gastric acid secretion. Omeprazole inhibits secretion of gastric acid by blocking the hydrogen-potassium-adenosine triphosphatase enzyme system, the so-called 'proton pump' of the gastric parietal cell. It is an effective treatment for gastric and duodenal ulcers and particularly for erosive reflux oesophagitis. Orally administered Omaprin (Omeprazole) is absorbed rapidly but to a variable extent. Following absorption Omaprin is almost completely metabolized and rapidly eliminated mostly in the urine. Although the elimination half-life from plasma is short, being reported to be 0.5 to 1.5 hours, its duration of action with regard to inhibition of acid secretion is much longer and it is suggested that its distribution to the tissues particularly to the gastric parietal cells accounts for this action. Omaprin is highly bound (about 95%) to plasma proteins.