LEFEX^® 500

Antibiotic

Levofloxacin Hemihydrate

Lefex® 500 contains levofloxacin 500 mg (as levofloxacin hemihydrate), a broad-spectrum fluoroquinolone antibiotic used for susceptible bacterial infections. Chemically levofloxacin is a chiral fluorinated carboxyquinolone. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby blocking DNA replication and producing a bactericidal effect.

Dosage form: Tablet
Strength: 500 mg
Composition: Each film coated tablet contains Levofloxacin Hemihydrate USP equivalent to Levofloxacin 500 mg.
Pack sizes: Lefex 500 Tablet: Each box contains 3 blister strips of 10 tablets.

Manufactured by Doctor's Chemical Works Ltd.

Prescribing information

Indications

Levofloxacin is indicated for the treatment of mild, moderate and severe infections caused by susceptible strains of the designated micro-organisms in the condition listed below: • Acute maxillary sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis. • Acute bacterial exacerbation of chronic bronchitis due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis. • Community-acquired pneumonia due to Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae. • Uncomplicated & complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus. • Acute pyelonephritis caused by Escherichia coli. • Uncomplicated & complicated skin and soft tissue infections including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections, due to Staphylococcus aureus, Streptococcus pyogenes, Proteus mirabilis or Enterococcus faecalis. • Enteric infections caused by Enterobacter sp., Escherichia coli, Campylobacter sp., Vibrio cholerae, Shigella sp., Salmonella sp.