THEODOX^® 200

Bronchodilator

Doxophylline

Theodox contains doxophylline INN 200 mg, a xanthine bronchodilator used to help relieve bronchospasm in asthma and COPD. After oral administration, doxophylline acts mainly by inhibiting phosphodiesterase activity (notably PDE4), which increases intracellular cAMP and relaxes bronchial smooth muscle, improving airflow. Compared with theophylline, it has lower affinity for adenosine receptors, which is associated with a better tolerability profile in many patients.

Dosage form: Tablet
Strength: 200 mg
Composition: Theodox 200 Tablet: Each film coated tablet contains Doxophylline INN 200 mg.
Pack sizes: Theodox 200 Tablet: Each box contains 5X10 tablets in Alu-PVC blister pack.

Manufactured by Doctor's Chemical Works Ltd.

Prescribing information

Pharmacology

Theodox (Doxophylline) is a novel bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxophylline selectively inhibits phosphodiesterase-4 enzyme, thereby relaxing bronchial smooth muscle. However, differently from Theophylline, Doxophylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxophylline also inhibits Platelet Activating Factor (PAF) and generation of leukotriene.